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The cells of a Gallifreyan body would be repaired, restored and re-organised, resulting in a wholly new physical form.
He also input a parameter of twelve regenerative cycles to avoid decaying biogenic molecules.(AUDIO: Zagreus) Another explanation stated that Time Lords had triple-helix DNA: the third strand was added by Rassilon to enable regeneration.(PROSE: The Crystal Bucephalus) According to Madame Vastra, the Eleventh Doctor theorised that exposure over billions of years to the Untempered Schism contributed to the Time Lords' ability to regenerate.(TV: A Good Man Goes to War) Time Lords released massive amounts of a hormone called lindos in moments of extreme trauma, and it was this hormone which triggered regeneration.(TV: Logopolis, Time and the Rani, Doctor Who, Utopia, Let's Kill Hitler, Hell Bent, PROSE: Interference - Book Two) It could also be invoked by choice, whether voluntary (TV: Destiny of the Daleks, The Night of the Doctor, Nightmare in Silver) or involuntary.(TV: The War Games) Conversely, regeneration could be prevented by choice, although choosing not to regenerate from fatal damage was essentially an act of suicide.
(TV: Last of the Time Lords) Different explanations were given for the process of regeneration.
One theory held that Cardinal Rassilon had been investigating a method of regenerating decayed and diseased tissue via a series of self-replicating, biogenic molecules.
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Regeneration was the process by which Time Lords and others renewed themselves, causing a complete physical and often psychological change.
It could happen because of severe illness, (TV: Planet of the Spiders, The Caves of Androzani, The End of Time, Day of the Moon; AUDIO: The Brink of Death) old age/fatigue (TV: The Tenth Planet, The Day of the Doctor, The Time of the Doctor) or injury.