Non sedating muscle
In particular, the invention is directed to the treatment of cerebral ischemia, head trauma and other acute neurologic injuries, using non-sedating barbiturates.
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In such cases, a non-sedating barbiturate is used prophylactically in individuals at risk for ischemic damage. These compounds can be given in oral form as a tablet, capsule, liquid or via intravenous or other parental routes.
There are many circumstances where individuals at risk of cerebral ischemia are clearly identified in advance, for example: individuals undergoing cardiac surgery or carotid endarterectomy, and individuals with atrial fibrillation, transient ischemic attacks (TIAs), bacterial endocarditis, strokes, or subarachnoid hemorrhage due to a cerebral aneurysm.
Preferred compounds are in the family of diphenylbarbituric acid and analogs. Methods of providing neuroprotection are disclosed comprising administering a non-sedative barbiturate compound in an amount sufficient to achieve neuroprotection in a mammalian subject. According to the invention, it is possible to separate the anticonvulsant and sedative effects of barbiturates, and neuroprotection correlates much better with the anticonvulsant rather than the sedative effect of barbiturates.
Preferred compounds are in the family of diphenylbarbituric acid and analogs. This invention differs from the prior art in the recognition of specific compounds, their modifications and dosages that are effective in neuroprotection but that were not previously recognized.
Preferred doses for a neuroprotective effect exceed the dosage of a corresponding sedative barbiturate without sedative side-effects such as anesthesia and death. The present invention is a method for providing neuroprotection to a mammal, preferably a human.
The invention avoids the toxicity and sedative effects of barbiturates known in the prior art without loss of efficiency.